is it possible to establish peering connection between an instances in different region and different accounts ?

YES — different Region + different AWS accounts is supported by inter region peering connection
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vignesh 15 hours ago
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To provide internet to a instance in Private subnet
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Internet Gateway (IGW) establishes communication between VPC and the internet
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unique hardware identifier assigned to a device's network interface such as an Ethernet or Wi-Fi adapter. It is used to identify devices on ..
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